Yohimbine is an alkaloid found in the inner bark of a tree that grows in southern Africa, Corynanthe yohimbe. Yohimbe has been used for centuries as an aphrodisiac, and alkaloids derived from this tree have been studied in depth. Yohimbine is now used primarily in veterinary medicine and in the treatment of erectile dysfunction, and it may also be useful in the treatment of obe...sity.
How does yohimbine work?
Yohimbine works by blocking alpha(2) adrenoreceptors. There are a number of feedback mechanisms that prevent the release of norepinephrine (NE), one of the body's primary lipolytic hormones. When NE is released, such as in periods of stress or after taking a sympathomimetic (such as ephedrine), it stimulates both the alpha and beta adrenoreceptors. Stimulation of the beta adrenoreceptors causes the breakdown of fat while stimulating the alpha(2) adrenoreceptors has the opposite effect, preventing the release of NE and lipolysis. Yohimbine prevents this negative feedback mechanism, thus increasing NE release and lipolysis.
There are a number of reasons why alpha(2) inhibition is specifically useful. First, while the beta-adrenergic system primarily controls lipolysis during periods. of intense activity, during rest, which makes up most of our day, the alpha-adrenergic system is in control. Also, "stubborn fat" areas – usually the abdominal area in men and the glutofemoral area in women – contain a higher ratio of alpha(2) receptors, making yohimbine particularly effective in these areas (whereas other drugs that increase NE may be somewhat counterproductive). Finally, alpha(2) blockade increases blood flow in adipose tissue which prevents fat from being retained in the area.
What other benefits does yohimbine have?
Aside from being a fat loss agent, yohimbine is well known as a sexual stimulant for men AND women. Studies indicate that it increases copulatory behavior and reduces sexual exhaustion in male rats. A recent review of the literature found that yohimbine, especially in combination with drugs that facilitate the action of nitric oxide, is effective in the treatment of male erectile dysfunction. Yohimbine also works very well on both sexes.
Serving Size : 1 Capsule
Servings Per Container : 90
Ingredients : Yohimbine HCL 3mg
Recommended Usage: Take one capsule with water 2-3 times per day, ideally on an empty stomach.
